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$1,500.00
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Personalized Gene Detection Kit for Tracking Cancer Signature Mutations
(Based on real-time PAP nucleic acid amplification

Intended use

Each cancer harbor many personalized signature somatic mutations, driver or passenger, that can be identified by sequencing the tumor tissue from surgery or biopsy. 

Dying tumor cells release small pieces of their DNA, that contains the same mutations, into the blood. This cell-free circulating DNA in the blood can enter the urine through the renal filter. 

Through ultra-high sensitive detection of the already-identified mutations in plasma or urine, the kits can be used for 1) early monitoring of cancer relapse, and 2) early monitoring of acquired drug resistance.

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Detection principle

This kit uses pyrophosphorolysis activated polymerization (PAP)technology to specifically amplify the mutant DNA but not wildtype DNA molecules. The amplified product is measured in real time fluorescence format.

Samples

Plasma and urine.

Advantages

1. High sensitivity: ability to detect a single copy of signature somatic mutations.

2. High specificity: virtually no false positive amplifications even in the presence of heavy background of wildtype DNA.

3. Freeze-dried format: much earlier and user-friendly manipulation.

4. Non-invasive sampling: plasma and urine samples can be applied.